RESUMEN
Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED was performed. We searched for the terms "erectile dysfunction" and "stem cell therapy" in PubMed and Clinicaltrials.gov. Literature searching was conducted in English and included articles from 2010 to 2022. Results: New treatment modalities for ED involving stem cell therapy are not only conceived with a curative intent but also aim to avoid unnecessary adverse effects. Several sources of stem cells have been described, each with unique characteristics and potential applications, and different delivery methods have been explored. A limited number of interventional studies over the past recent years have provided evidence of a safety profile in their use and promising results for the treatment of ED, although there are not enough studies to generate an appropriate protocol, dose or cell lineage, or to determine a mechanism of action. Conclusions: Stem cell therapy is a novel treatment for ED with potential future applications. However, most urological societies agree that further research is required to conclusively prove its potential benefit.
RESUMEN
Acidifying treatment and control of urinary pH may be an effective strategy to address recurrent lithiasic disease secondary to infective calculi. We present the case of a 39-year-old man with bilateral urolithiasis that led to episodes of complicated Reno ureteral colic.After undergoing multiple treatments by retrograde endourological surgery, he presented recurrence and progression of lithiasis disease, finally requiring percutaneous approach for treatment of a coralliform stone, after which he was free of lithiasis. It was then decided to start treatment with an acidifying oral supplement and home pH control by means of an electronic medical device as a complement to the surgeries he underwent, thus achieving stability of the disease, with absence of urinary tract infection or lithiasis recurrence.The patient, with poor adherence to previous treatments, presented in this case a correct follow-up of the treatment, as well as a high level of satisfaction with it.
El tratamiento acidificante y el control del pH urinario pueden constituir una estrategia eficaz para abordar la enfermedad litiásica recurrente secundaria a cálculos infectivos. Presentamos el caso de un varón de 39 años con urolitiasis bilaterales que le condicionaron episodios de cólicos renoureterales complicados.Tras ser sometido a múltiples tratamientos mediante cirugía endourológica retrógrada, presentó recidiva y progresión de enfermedad litiásica, precisando finalmente abordaje percutáneo para tratamiento de un cálculo coraliforme, tras lo cual queda libre de litiasis. Se decide entonces iniciar tratamiento con suplemento oral acidificante y control domiciliario de pH mediante dispositivo médico electrónico como complemento a las cirugías a las que fue sometido, logrando así estabilidad de enfermedad, con ausencia de cuadros de infección urinaria ni recidiva litiásica.El paciente, con mala adherencia a tratamientos previos, presentó en este caso un correcto seguimiento del tratamiento, así como elevado nivel de satisfacción con el mismo.
Asunto(s)
Cálculos Renales , Litiasis , Litotricia , Infecciones Urinarias , Urolitiasis , Adulto , Humanos , Riñón , Cálculos Renales/terapia , Litiasis/cirugía , Masculino , Urolitiasis/terapiaRESUMEN
El tratamiento acidificante y el control del pHurinario pueden constituir una estrategia eficaz para abor-dar la enfermedad litiásica recurrente secundaria a cálcu-los infectivos. Presentamos el caso de un varón de 39 añoscon urolitiasis bilaterales que le condicionaron episodiosde cólicos renoureterales complicados. Tras ser sometidoa múltiples tratamientos mediante cirugía endourológicaretrógrada, presentó recidiva y progresión de enfermedadlitiásica, precisando finalmente abordaje percutáneo paratratamiento de un cálculo coraliforme, tras lo cual quedalibre de litiasis. Se decide entonces iniciar tratamiento consuplemento oral acidificante y control domiciliario de pHmediante dispositivo médico electrónico como comple-mento a las cirugías a las que fue sometido, logrando asíestabilidad de enfermedad, con ausencia de cuadros deinfección urinaria ni recidiva litiásica. El paciente, con mala adherencia a tratamientos previos,presentó en este caso un correcto seguimiento del tratamien-to, así como elevado nivel de satisfacción con el mismo.(AU)
Acidifying treatment and control of urinarypH may be an effective strategy to address recurrent lithia-sic disease secondary to infective calculi. We present thecase of a 39-year-old man with bilateral urolithiasis thatled to episodes of complicated Reno ureteral colic. Afterundergoing multiple treatments by retrograde endourolog-ical surgery, he presented recurrence and progression oflithiasis disease, finally requiring percutaneous approachfor treatment of a coralliform stone, after which he wasfree of lithiasis. It was then decided to start treatment withan acidifying oral supplement and home pH control bymeans of an electronic medical device as a complement tothe surgeries he underwent, thus achieving stability of thedisease, with absence of urinary tract infection or lithiasisrecurrence.The patient, with poor adherence to previous treatments,presented in this case a correct follow-up of the treatment,as well as a high level of satisfaction with it.(AU)
